Endocrine Abstracts

Introduction: Prevalence of CS without specific signs is thought to be high, which might be an indication for its general screening. However, conclusive data about its diagnostics is absent.Design: 189 overweight patients were studied. Nobody had clinical evidence of hypercortisolism. Diagnostic of CS was 1-mg overnight dexamethasone suppression test (1-mg DST; cut off 50 nmol/l) as a screening; midnight plasma cortisol (MPC) (<207 nmol/l) and 24-h u...

Obesity is a polyetiological and incompletely studied disease. Recent publications link the special composition of the gut microbiota not only with obesity, but also with its metabolic profile1, 2. To study the characteristics of the gut microbiota in patients with different phenotypes of obesity, 37 patients were examined. In addition to determining the quantitative composition of the gut microbiota by the Real-time PCR method, all participants were determined by l...

Currently, it has been established that obesity is a heterogeneous disease. There are metabolically healthy (MHO) and metabolically unhealthy obesity (MNHO) depending on the presence of cardiometabolic disorders. Potential factors that differentiate obesity into phenotypes include the gut microbiome and endocrine activity of adipose and muscle tissue. Purpose of the study was to compare intestinal microbiome and adipomyokine profile in patients with different obesity phenotype...

Introduction: Thyrotoxicosis syndrome is a clinical syndrome, associated with the negative effect of strong thyroid hormone excess on the organism. In most cases women with thyrotoxicosis syndrome in postpartum period have postpartum thyroiditis, caused by reactivation of the immune system after gestational suppression. However sometimes Graves disease can manifest during the postpartum period, this condition also results in thyrotoxicosis syndrome and requires radical thyroid...

Background: Cushing’s disease (CD) develops as a result of ACTH-secreting pituitary adenoma. Transsphenoidal selective surgery (TSS) is the first-line therapy, and success is largely determined by the experience of the surgeon. There are several reasons for the persistence of the disease, but it is almost impossible to predict such an outcome in advance, which leads to multiple interventions and has a pronounced effect on the quality of life of patients.<p class="abs...

Background: Parathyroid cancer is a rare pathology, approximately 2 cases per 10, 000, 000 people/year. The five-year survival rate for this disease ranges from 20–85%, and the ten-year survival rate is approximately 15–80%. Timely detection and compliance with algorithms for parathyroid gland cancer diagnostics allows surgical treatment and maximum positive prognosis for patient.Clinical case: Patient 18 y.o., was presented with complaints t...

Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary condition that most often manifests with primary hyperparathyroidism followed by other syndromes, but there are other variations in the clinical presentation, which can increase the risk of medical error and worsen prognosis. A 32-year-old woman presents with complaints of low glucose levels, hunger, weakness, sleep disturbances, which are stopped by taking sweets. At the age of 16, a pituitary macroadenoma, prola...

Background: Graves’ disease in combination with thyroid nodules is more common in women. However, more than one in three patients has carcinoma. Unfortunately, thyroid cancer is most frequently detected accidentally after a thyroidectomy for Graves’ disease, despite the wide possibilities of modern diagnostic methods.Clinical case: A 55-year women complained of discomfort in the neck, sweating, irritability, palpitation. From anamnesis: in 20...

Osteoporosis is a systemic skeletal disease characterized by a decrease in bone strength and an increased risk of fractures. In the structure of osteoporosis, secondary osteoporosis is 5% in women and 20% in men. Clinicians need to exclude the secondary nature of osteoporosis, since under the ’mask’ of mineral metabolism disorders, more rare and dangerous diseases can arise. A 65-years-old women presents with complaints of three low-traumatic fractures in the last ye...

Thyroid orbitopathy (TO) is an autoimmune inflammatory disease of retroocular tissues. Mostly, TO is associated with Graves’ hyperthyroidism. The development of TO is accompanied by pathological changes in the soft tissues of the orbit with damage to the optic nerve and cornea, the accessory apparatus of the eye. Despite the presence of specific symptoms, the diagnosis of TO causes problems for doctors. A 61-year-old man complained of discomfort in the eyes, double vision...